Risks and treatment for recurrent intraepithelial cervical lesions

Background. Persistently high incidence of cervical cancer in Russia and significant number cases detected the late stages necessitate improvement secondary prophylaxis this disorder. Aim. To assess risk factors for recurrent high-grade intraepithelial neoplasia (CIN2+) (high grade squamous lesions, HSIL) after conization. Materials methods. This study included 62 patients with HSIL treated Novosibirsk Regional Clinical Oncology Dispensary, E. N. Meshalkin National Medical Research Center, “Zdorovye” LLC, “Avismed” Tomsk Center Russian Academy Sciences, Federal Specialized Care Technologies, Biomedical Agency Federation 2017–2021. We analyzed patients’ human papillomavirus (HPV) status, performed repeated examination excised tissue specimens to evaluate severity lesions resection margins, as well immunohistochemical examinations. found that mean time cytologically confirmed was 16.0 ± 5.6 months. All were HPV-positive. Repeated histological demonstrated 18 samples had positive margins or endocervical crypt involv ement. Fifty-seven staining p16 at examination; 46 Ki-67 >30 %, which indicated recurrence. Treatment excision up healthy tissues, followed by intravaginal therapy Cervicon-DIM 100 mg twice a day (for 3 months). Follow-up examinations 18.0 6.2 months on average showed no HPV persistence Conclusion. Endocervical involvement along primary margin, underestimated depth (at first surgery), infection are main dysplasia carcinoma situ . Combination treatment includes additional subsequent course is sufficient effective.